The exterior of the mansion.

The Millenium Institute for the Gifted is a special institute founded and led by Professor Robert Langdon to train young Deviants in controlling their powers and help foster a friendly human-deviant relationship. The mansion is extraordinarily large and surrounded by a lush greenery and open space. The Institute is welcome for Deviants of all ages, though the more common ones to attend are much younger deviants, teenage, and even adults.

While it initially began as a normal mansion it was soon decided by Professor Langdon himself that it would be better suited to become a school for young deviants. Sometime between the late 1700s and early 1900s, a large Neoclassic mansion was constructed on the land near Breakstone Lake just outside of Salem Center, New York. The estate was inherited by Philip Langdon and he lived there with his wife, Minerva and their son, Robert, until Philip's untimely, accidental death.

Robert Langdon was born and raised in the mansion. After Philip's death, Minerva married his once colleague. Minerva died not long after the marriage, and the ownership of the estate passed on to Robert. Robert is the tenth generation Langdon to own the mansion.

After graduating from Oxford University, being drafted in the Vietnam War, and battling an unknown creature in Cairo, Egypt, Langdon decided to devote his life to protecting humanity from malevolent Deviants and safeguarding innocent Deviants from human oppression, believing that both could peacefully coexist. Although Langdon still believes that while many Deviants did not choose this malevolent lifestyle and instead became as such from society, he would attempt to reason with the more sociopathic Deviants.

Robert Langdon worked with fellow mutation expert, Dr. Nancy Mullen and Dr. John Abelson, and they began discussing the idea of founding a school for Deviants. Professor Langdon's first student was the 18-year-old Maxine Caulfield, who had been traumatized when her powers of time manipulation had unwittingly brought a storm to her town of Arcadia Bay. Later, Langdon met a police officer who was a friend of his, that introduced him to a young deviant known as Derek Phillips. Derek soon was enticed into the mansion and, over the following months, he recruited more and more students. The school was officially open in the year 2014 and became an icon across the world, to where Langdon was offered to build more of the schools in different regions of the world.